RB depletion is required for the continuous growth of tumors initiated by loss of RB.
The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this Espresso Machine (Super-Automatic) inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation.RB has been extensively studied, but its mechanisms of action in normal and cancer cells remain only partly understood.H